Tuesday, July 3, 2012

Q: What is Xanthogranulomatous pyelonephritis?

Answer: Xanthogranulomatous pyelonephritis is characterized by granulomatous abscess formation, kidney destruction, and a clinical picture that may resemble renal cell carcinoma. Patients present with recurrent fevers, bouts of urosepsis and a painful renal mass. Microscopically, there are granulomas and lipid-laden macrophages (hence the term xantho = yellow). Antibiotics are used just as a temporizing measure in patients. Usually Nephrectomy is required. Limited cases may get away with partial nephrectomy.

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