Thursday, December 18, 2014

Choose one

Q: Amiodarone (increase) or (decrease) the effect of Sildenafil?



Answer: Increase

Amiodarone inhibits the action of the cytochrome P450 isozyme family, which reduces the clearance of many commonly used drugs in ICU including Digoxin, Sildenafil, Theophylline and Warfarin.



Reference:

Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr, et al. ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association [Published erratum appears in J Am Coll Cardiol 1999; 34:1850]. J Am Coll Cardiol. 1999;33:273–82.

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