Q: Amiodarone (increase) or (decrease) the effect of Sildenafil?
Amiodarone inhibits the action of the cytochrome P450 isozyme family, which reduces the clearance of many commonly used drugs in ICU including Digoxin, Sildenafil, Theophylline and Warfarin.
Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr, et al. ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association [Published erratum appears in J Am Coll Cardiol 1999; 34:1850]. J Am Coll Cardiol. 1999;33:273–82.