Q: Diabetic patients may require? (select)
A) Higher dose of clopidogrel
B) Lower dose of clopidogrel
Diabetic patients may require higher than standard dose of clopidogrel due to the reason that by default they have a higher percent of circulating immature platelets. This characteristics may counteract the inhibitory effect of clopidogrel on platelets. Although evidence in this regard is weak. Diabetic patients may respond better to other platelet inhibitor like prasugrel or ticagrelor.
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3. Gurbel PA, Bliden KP, Butler K, et al. Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. Circulation 2010; 121:1188.