Q; Is Digoxin a diuretic?

A: Yes it has direct diuretic property! Digoxin increases diuresis by at least 4 mechanisms

• Direct vasodilation
• Increased CO improves renal hemodynamics
• Inhibition of tubular reabsorption of sodium, of renal Na+ -K+-ATPase, and of concentrating and diluting ability
• Increased secretion of atrial natriuretic peptide
  

Reference:

1. Rahimtoola SH, Tak T. The use of digitalis in heart failure. Curr Probl Cardiol. 1996; 21: 781–756