Q: Fomepizole and ethanol are both use as treatment in Ethylene Glycol toxicity. What other medicines should be considered as adjuvant therapy in Ethylene Glycol toxicity?

Answer: Pyridoxine and Thiamine Pyridoxine (Vitamin B6) and Thiamine are cofactors in ethylene glycol metabolism and may be administered parenterally. On side note, while preparing antidotes early treatment with sodium bicarbonate should be initiated essential to correct acidosis. It may require upto 500-1000 mmol of bicarbonate within the first hours, especially if antidotal therapy is delayed.