Q: Zosyn (Piperacillin/tazobactam) need to be adjusted in renal failure patients on hemodialysis. Does it need to be adjusted in patients on CVVHD?


Answer: NO

Dose Zosyn (Piperacillin/tazobactam) does not need to be adjusted in renal failure patients on CVVHD. It would be as like a patient with normal kidney function.

In patients on HD dose is usually: 2.25 g IV Q8h
In patients on CVVHD, dose is usually: 3.375 g IV Q6h or 4.5g IV Q8h