Answer: About 24 hours
In absence of active bleeding, oral Vitamin K is always preferable. Only disadvantage is its slow action. IV vitamin K takes about 6 to 12 hours to achieve expected INR and oral Vitamin requires about 24 hours.
Though IV vitamin is faster than oral Vitamin K, it carries the chances of anaphylactoid reaction even with minor dose. Also less known side effect of IV Vitamin K is over-correction of anticoagulation.
Comparison of Oral vs Intravenous Phytonadione (Vitamin K1) in Patients With Excessive Anticoagulation - A Prospective Randomized Controlled Study : Arch Intern Med. 2003;163(20):2469-2473.
Anaphylaxis after low dose intravenous vitamin K - J Emerg Med. 2003 Feb;24(2):169-72.
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