Q: 52 year old male in ICU is under treatment for MRSA pneumonia with Zyvox (Linezolid). Patient was taken for "I n D" (incision and drainage) by surgery. Post-op patient has symptoms of shivering. Resident wrote order for Demerol. Pharmacy called you to confirm the order. What would be their concern? 



Answer: serotonin syndrome 

 Meperidine (Demerol) with linezolid (Zyvox) may cause serotonin syndrome with symptoms of confusion, hallucination, tachycardia, fever, sweating, muscle spasm etc.