Q: What is Prothrombin complex concentrates (PCC)?


Answer: Prothrombin complex concentrates (PCC) are derived from human plasma and contain the vitamin K dependent coagulation factors II, VII, IX, and X at varying concentrations. Several international guidelines as well as American College of Chest Physicians, now recommends PCC for warfarin reversal in patients with serious bleeding. The use of PCC in the United States (US) is still not widespread.


Prothrombin Complex Concentrate Versus Standard Therapies for INR Reversal in Trauma Patients Receiving Warfarin - Ann Pharmacother July/August 2011 vol. 45 no. 7/8 869-875