Q: In which organ dysfunction, Eptifibatide (Integrilin) should be used with caution?

Answer: Renal Dysfunction.

Eptifibatide (Integrilin)is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class used in Acute Coronary Syndome and in patients undergoing Percutaneous Coronary Intervention (PCI).

Eptifibatide gets eliminated via renal route. Bolus dose remains same (180 µg/kg) but continuous infusion should be curtail back to half dose i.e. 1.0 µg/kg/min.

Patients undergoing, Percutaneous Coronary Intervention (PCI) - a second bolus dose of 180-µg/kg is given after 10 minutes of the first bolus.