Q: Initiation of ACE-inhibitors and ARBs (angiotensin receptor blockers), may cause approximately what level of increment in baseline creatinine - and it should be OK!?

Answer:  ACEIs and ARBs could result in a 25% "permissible" increment of baseline serum creatinine and should not become an indication to stop these families of drugs.

But, a persistent upward trend of serum creatinine while on ACEIs and ARBs should be an alert to the possibility of bilateral renal artery stenosis or renal artery stenosis in solitary functioning kidney.