Q: Should PO amiodarone be given with food or empty stomach?

Answer:  With food

It is well known that PO amiodarone has variable bioavailability ranging from 22 to 95%. Interestingly, it has shown to have better absorption if it is taken with food.

Reference:

Siddoway LA (2003). "Amiodarone: guidelines for use and monitoring" - American Family Physician 68 (11): 2189–96. (http://www.aafp.org/afp/2003/1201/p2189.html)