Q: What disadvantage Lactate Ringer (LR) has when it comes to compatibility while using IV lines?

Answer:

LR contains calcium in lactated Ringer’s in amount of 1.5 mmol/L. While using same IV lines or as a 'drip line', Ca+ in LR can bind to some drugs and may reduce their efficacy.

Another under-appreciated effect in surgical ICUs is calcium binding to the citrated anticoagulant in blood products. This can inactivate the anticoagulant and may promote the formation of clots in donor blood.