Q; Why "Bridging of warfarinization" is recommended?
Answer:
For the first 48 to 72 hours of initiation of warfarin, the levels of protein C and protein S, usually known as proteins of anticoagulation, drop faster than pro-coagulation proteins such as factor II, VII, IX and X. Henceforth, bridging anticoagulant therapies (such as heparin) are recommended to be used during this temporary hypercoagulable state.
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