Q: What bacteria E.coli has to
do with Filgrastim (Neupogen)?
Answer:
Filgrastim (Neupogen) is a granulocyte colony-stimulating
factor (G-CSF) analog used to stimulate the proliferation and differentiation of
granulocytes. It is produced by recombinant DNA technology.
The
gene for human granulocyte colony-stimulating factor is inserted into the
genetic material of Escherichia coli. The G-CSF then produced by E. coli is
different from G-CSF naturally made in humans.
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