Q: What is the the last resort treatment in severe refractory ethanol intoxication?

Answer:  Hemodialysis

Hemodialysis very effectively get rid of ethanol from the blood but it is reserved for severe cases where neurological or hemodynamic situation may become life threatening.

In most cases of ethanol toxicity, supportive treatment is enough to ride off the intoxication phase with IV fluid, IV thiamine, preventing hypoglycemia, preventing electrolyte imbalance, transient use of vasopressors and maintaining normothermia.