Q: Which pain medicine should be avoided while patient is getting Linezolid (Zyvox)?

Answer: Meperidine

Meperidine along with Linezolid may cause life threatening Serotonin Syndrome. 

References:

1. Das PK, Warkentin DI, Hewko R, Forrest DL.- Serotonin syndrome after concomitant treatment with linezolid and meperidine.- Clin Infect Dis. 2008 Jan 15;46(2):264-5.

2. Elizondo Armendáriz JJ, Pellejero Hernando E, Noceda Urarte MM, Gutiérrez Valencia M. - Probable serotonin syndrome due to linezolid and meperidine interaction, Farm Hosp. 2012 Sep-Oct;36(5):448-9. Epub 2012 Mar 21.