Q: What is the optimum time of administration of Nimodipine in Subarachnoid Hemorrhage (SAH)?
Answer: At least within 96 hours to 21 days
In subarachnoid hemorrhage (SAH), nimodipine's is used primarily in the prevention of cerebral vasospasm. It should be started as early as possible, at least within 4 days of a subarachnoid hemorrhage (SAH) and should be continued for 21 days.
Nimodipine is a calcium channel blocker and has selectivity for cerebral vasculature.
Readers are recommended to browse reference # 2 below.
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References:
1. Sokolowski JD, Chen CJ, Soldozy S, Mastorakos P, Burke RM, Nguyen JM, Myers KM, Kalani MYS, Park MS. Nimodipine after aneurysmal subarachnoid hemorrhage: Fourteen-day course for patients that meet criteria for early hospital discharge. Clin Neurol Neurosurg. 2021 Jan;200:106299. doi: 10.1016/j.clineuro.2020.106299. Epub 2020 Oct 8. PMID: 33092929.
2. Samseethong T, Suansanae T, Veerasarn K, Liengudom A, Suthisisang C. Impact of Early Versus Late Intravenous Followed by Oral Nimodipine Treatment on the Occurrence of Delayed Cerebral Ischemia Among Patients With Aneurysm Subarachnoid Hemorrhage. Ann Pharmacother. 2018 Nov;52(11):1061-1069. doi: 10.1177/1060028018778751. Epub 2018 May 22. PMID: 29783859. https://pubmed.ncbi.nlm.nih.gov/29783859/
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