Q: Why flumazenil should be use with caution in patients with Cocaine overdose

Answer: Use of flumazenil in the cocaine-intoxicated patient may induce seizures.

It is common for patients to present with simultaneous overdose/abuse of benzodiazepine and cocaine. Administration of flumazenil to patients with benzodiazepine use may become life threatening . Cocaine is a gamma-aminobutyric acid (GABA) antagonist that may be potentiated by flumazenil.