Q: Methylene Blue can be use as a treatment in which infectious disease? 


 Answer: Malaria 

 Actually Methylene Blue has been used as an anti-malarial for almost a century. It has been shown to play role again in malarial treatment with increasing resistance of P. falciparum to front line treatments. 

Mechanism of action: Methylene Blue, a specific inhibitor of P.falciparum glutathione reductase has the potential to reverse CQ resistance and it prevents the polymerization of haem into haemozoin similar to 4-amino-quinoline antimalarials. 

Dose: A dose of 36-72mg/kg over 3 days. 



 Reference:

 Meissner Peter E, Germain Mandi, Boubacar Coulibaly, et al. - Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine. Malaria Journal. 2006;5:84.