A note on Digoxin-Amiodarone interaction

Amiodarone may decrease the clearance of digoxin, causing prolonged digoxin activity. Also, there may be a synergistic effect on the sinus node. Digoxin level should always be obtained prior to initiation of amiodarone therapy. Usually, it requires to decrease the dose of digoxin by 25-50% and close monitoring of digoxin levels. In addition, electrolytes should also be closely monitored. Patients with hypothyroidism needs extra attention.