pulmonary complication with Daptomycin infusion

Q: Which life-threatening pulmonary complication may happen with Daptomycin infusion?

Answer: Eosinophillic Pneumonia

According to the FDA report, seven cases of eosinophilic pneumonia were confirmed between 2004 and 2010. The seven confirmed cases were all aged 60 or older, and symptoms appeared within 2 weeks of therapy initiation.

To date, the scientific literature continues to report cases. 

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References:

1. Acute Eosinophilic Pneumonia Secondary to Daptomycin: A Report of Three Cases - Becky A. Miller, Alice Gray, Thomas W. LeBlanc, Daniel J. Sexton, Andrew R. Martin, and Thomas G. Slama - Clin Infect Dis. (2010) 50 (11): e63-e68.

2. Somoza-Cano FJ, Makadia A, Cruz-Peralta MP, Zakarna L, Demyda E, Al Armashi AR, Patell K, Altaqi B. Acute Eosinophilic Pneumonia Secondary to Daptomycin. Cureus. 2021 Nov 9;13(11):e19403. doi: 10.7759/cureus.19403. PMID: 34926005; PMCID: PMC8658045.

3. Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L. Daptomycin-Induced Eosinophilic Pneumonia: A Case Report and Systematic Review. Chemotherapy. 2024;69(2):85-99. doi: 10.1159/000535190. Epub 2023 Nov 14. PMID: 37963447.