Q: What is considered as an endpoint success in Barbiturate coma therapy (BCT)  from ICP (intra cranial pressure) control perspective in neurotrauma patients?

Answer: ICP < 20 mmHg for at least 48 hours, at a minimum

Patients, whose ICPs are successfully controlled by pentobarbital, had at least five times greater chance of survival. 

References:

Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD. High dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg. 1988;69:15–23.

Etienne D, Jacques B, Arlette V, Florence L, Jean LV. Barbiturate coma for intracranial hypertension: clinical observations. J Crit Care. 2002;17:58–62.

Horsley JS. The intracranial pressure during barbital narcosis. Lancet. 1937;1:141–143.

Michael WL, Scott AD, Mary ES, Roger RB, Dan RT. The efficacy of barbiturate coma in the management of uncontrolled intracranial hypertension following neurosurgical trauma. J Neurotrauma. 1994;11:325–331.