Q:
What is the general overlap time between IV insulin and SQ insulin at resolution
of DKA
Answer: About 60 minutes (few recommends upto 2 hours)
Patients with known diabetes may be given
insulin at the dosage they were receiving before the onset of DKA. In patients
with newly diagnosed diabetes, an initial insulin dose of 0.6 unit/kg/day is
usually sufficient. Overlapping of subcutaneous
insulin and intravenous insulin infusion for 1- or
2-h avoid recurrence of hyperglycemia or ketoacidosis.
Importantly, if patients are not able to eat, intravenous insulin
should be continued while an infusion of 5% dextrose in half-normal saline is
given at a rate of 100–200 mL/h.
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