Q: Which one side effect of Glucagon should be kept in mind if it is used for hypoglycemia?


Answer: Rebound fatal hypoglycemia

Glucagon depletes glycogen stores, and can cause a fatal rebound hypoglycemia. Glucagon is a very effective and quick antidote in hypoglycemia when regular glucose have low likelihood of effectiveness as in patients who are on regular Beta-Blockers. Glucagon rapidly counters the metabolic effects of insulin in the liver, causing glycogenolysis and release of glucose into the blood, raising the glucose  level by 30–100 mg/dL within minutes in mostly all types of diabetic hypoglycemia.