Q: Which of the following drug overdose may presents as non-cardiogenic pulmonary edema?

A) Phenytoin
B) Furosemide 
C) Salicylate
D) Propofol
E) Lorazepam


Answer: C

Salicylate-induced noncardiogenic pulmonary edema is usually seen as an acute on chronic salicylate poisoning. Elderly people are more prone to it. Salicylate-induced pulmonary edema is considered as an absolute indication for hemodialysis. 

Phenytoin toxicity does not produce pulmonary edema. Furosemide is usually the treatment of cardiogenic pulmonary edema. It should be use with caution in non-cardiogenic pulmonary edema. Propofol infusion syndrome may cause acute MI and subsequently cardiogenic pulmonary edema. Heroin and Methadone are known to produce non-cardiogenic pulmonary edema but Lorazepam is not.