Q: Which one of the following is the risk for Linezolid associated lactic acidosis?

A) Diabetes
B) Decrease GFR (golmerular filtration rate)
C) Previously documented bacteremia
D) Age
E) Duration of therapy



Answer: E

One recent study of 72 patients, published in International Journal of Infectious Disease showed that a longer duration of linezolid use, i.e more than 6 weeks use is one of the risk factors for metabolic acidosis. There was no statistically significant difference according to age, estimated glomerular filtration rate, or diabetes. 




Reference:

 Im JH, Baek JH, Kwon HY, Lee JS. - Incidence and risk factors of linezolid-induced lactic acidosis - J Infect Dis. 2015 Feb;31:47-52.