Q: What is the acceptable ischemic time between procurement and re-implantation of donor lung to recipient body? (select one)

A) Less than 2 hours
B) Less than 4 hours
C) Less than 6 hours
D) Less than 8 hours
E) There is no time limit (as far as organ is good)




Answer: D

Recommended optimal acceptable ischemic time between procurement and re-implantation of donor lung to recipient body is up to 8 hours, though institutions may accept  ischemic times of up to 12 hours. Studies have shown that the risks of primary graft dysfunction and 30 day mortality increase with more than 8 hours of ischemia.




Reference:

1.  de Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003; 167:490. 

2. Thabut G, Mal H, Cerrina J, et al. Graft ischemic time and outcome of lung transplantation: a multicenter analysis. Am J Respir Crit Care Med 2005; 171:786.