Q: How you define neutropenic fever assuming absolute neutrophil count (ANC) is less than 500 cells/microL?


Answer: Fever in neutropenic patients is defined as a single oral temperature of  101.0°F (38.3°C) or a temperature of 100.4°F(38.0°C) sustained for more than 1 hour. 



Reference:

Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis 2011; 52:e56.