A note on use of plasmapheresis  for central pontine myelinolysis(CPM) 

Data is limited but plasmapheresis has shown promising clinical benefit on CPM (also known as osmotic demyelination syndrome) if implement quickly on diagnosis, though MRI may not show any improvement. If nothing to loose, plasmapheresis could be of worth trying in such situations.



References: 

1.  Bibl D, Lampl C, Gabriel C, et al. Treatment of central pontine myelinolysis with therapeutic plasmapheresis. Lancet 1999; 353:1155. 

2. Grimaldi D, Cavalleri F, Vallone S, et al. Plasmapheresis improves the outcome of central pontine myelinolysis. J Neurol 2005; 252:734. 

3. Saner FH, Koeppen S, Meyer M, et al. Treatment of central pontine myelinolysis with plasmapheresis and immunoglobulins in liver transplant patient. Transpl Int 2008; 21:390.