A note on exacerbation of seafood allergy due to antacids 

Patients with allergy to seafood should take caution while taking antacids/antiulcer therapy. Antacids increase the gastric PH and consequently may impair the digestion of food proteins. Evidence is weak but pathophysiology suggests that antacids may increase risk of allergy to ingested seafood.




References: 

1. Untersmayr E, Schöll I, Swoboda I, et al. Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin Immunol 2003; 112:616. 

2. Untersmayr E, Vestergaard H, Malling HJ, et al. Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy. J Allergy Clin Immunol 2007; 119:711.