Q: Which of the following is regarded as antidote for valproic acid overdose?

A) N-acetylcysteine 
B) L-carnitine
C) Vitamin B6
D) Naloxone
E) Sodium Bicarbonate


Answer:  B 

Valproic acid toxicity which usually causes  hyperammonemia and  liver injury is in part mediated by carnitine deficiency. Various drug regimens  have been described. Literature clearly shows the reversal or prevention of toxic effects of valproic acid with carnitine administration. 





Reference: 

Perrott J, Murphy NG, Zed PJ. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother 2010; 44:1287.