Q: What could be one way of detecting the cause of Hepatocellular Carcinoma (HCC) radiologically?


Answer: 

If radiologically, HCC appears nodular, the probable cause is cirrhosis. And, if it shows infiltrative appearance, the probable cause of HCC is chronic hepatitis B.


Reference: 

Benvegnù L, Noventa F, Bernardinello E, et al. Evidence for an association between the aetiology of cirrhosis and pattern of hepatocellular carcinoma development. Gut 2001; 48:110.