Q: What is vasodilator-stimulated phosphoprotein (VASP) Index? 


 Answer: Vasodilator-stimulated phosphoprotein (VASP) Index, accurately detect biological clopidogrel resistance. Studies have shown that there is a strong correlation between stent thrombosis and a VASP index higher than 48%- 50%. 


Reference:

1. Barragan P, Bouvier JL, Roquebert PO, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv 2003;59:295–302.

2. Cuisset T, Frere C, Quilici J, et al. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non–ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol 2006;48:1339–45. 

 3. Blindt B, Stellbrink K, de Taeye A, et al. The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis. Thromb Haemost 2007;98:1329–34.