Q: One unit of cryoprecipitate (cryo) raises the fibrinogen level by how much?


Answer: Plasma fibrinogen level rise by approximately 7 to 10 mg/dL, with each unit of cryo transfusion. The usual formula to calculate the requirement of cryo is 1 unit of cryo per 10 kg of body weight. In massive surgical bleed, it should be calculated as 1 unit per 5 kg of body weight. One unit of cryo is about 10 to 15 mL in volume and is obtained from one unit of whole blood, and is about 200 to 400 mg in each unit of cryo.