Q: Intraarticular antibiotics should be considered as first line of therapy in severe septic arthritis?

A) True
B) False


Answer: B (False)

Actually intraarticular antibiotics are contraindicated as they may mount severe inflammatory response, and make clinical situation worse. Parenteral/oral antibiotics are capable of invading joint fluid and induce therapeutic levels.



Reference: 

Goldenberg DL, Reed JI. Bacterial arthritis. N Engl J Med 1985; 312:764.