Q; Which one of the following is expected in Cholesterol emboli? 

 A) Severe Leukocytosis 
B) Eosinophilia 
C) Triglyceridemia 
 D) Thrombocytopenia 
E) Require must exposure to anticoagulation 


 Answer: B

Particularly in the early phase of cholesterol emboli, majority of the patients develop hypereosinophilia. Though not proven but it is assumed that this is cytokine-mediated via interleukin 5 derived from vascular endothelium.


References: 

1.  Kasinath BS, Lewis EJ.  Eosinophilia as a clue to the diagnosis of atheroembolic renal disease. Arch Intern Med. 1987; 147: 1384–1385.

2. Cecioni I, Fassio F, Gori S, Giudizi MG, Romagnani S, Almerigogna F. Eosinophilia in cholesterol atheroembolic disease. J Allergy Clin Immunol. 2007; 120: 1470–1471;

3. Jucgla A, Moreso F, Muniesa C, Moreno A, Vidaller A. Cholesterol embolism: still an unrecognized entity with a high mortality rate. J Am Acad Dermatol. 2006; 55: 786–793