Q; Prednisone respond earlier to Immune thrombocytopenia (ITP) in adults than Dexamethasone?

A) True
B) False

Answer:  False

Different treatment modalities have different response time in ITP including even types of steroid.  Dexamethasone works faster than Prednisone. 

• Dexamethasone response time is 2 to 14 days, and
• Prednisone response time is 4 to 14 days

In cases where more rapid response is needed like in active bleeding, patients urgent invasive procedure etc, intravenous immune globulin (IVIG) should be used, which can increase platelet count within 24 to 48 hours.


References:

1.  Salib M, Clayden R, Clare R, et al. Difficulties in establishing the diagnosis of immune thrombocytopenia: An agreement study. Am J Hematol 2016; 91:E327. 

2. Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009; 113:2386.