Q; Which of the following anti-seizure medicine has been reported to cause sinus node dysfunction and heart blocks?
A) Carbamazepine
B) Tegretol
C) Diazepam
D) Lacosamide
E) Levetiracetam
Answer: D
Lacosamide, due to its action enhances the slow inactivation of voltage-dependent sodium channels. This results in cardiac conduction disturbances, mostly atrial fibrillation and atrioventricular block.
References:
1. Degiorgio CM. (2010) Atrial flutter/atrial fibrillation associated with lacosamide for partial seizures. Epilepsy Behav 18:322–324.
2. Krause LU, Brodowski KO, Kellinghaus C. (2011) Atrioventricular block following lacosamide intoxication. Epilepsy Behav 20:725–727.
3. Nizam A, Mylavarapu K, Thomas D, Briskin K, Wu B, Saluja D, Wong S. (2011) Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. Epilepsia 52:e153–e155.
A) Carbamazepine
B) Tegretol
C) Diazepam
D) Lacosamide
E) Levetiracetam
Answer: D
Lacosamide, due to its action enhances the slow inactivation of voltage-dependent sodium channels. This results in cardiac conduction disturbances, mostly atrial fibrillation and atrioventricular block.
References:
1. Degiorgio CM. (2010) Atrial flutter/atrial fibrillation associated with lacosamide for partial seizures. Epilepsy Behav 18:322–324.
2. Krause LU, Brodowski KO, Kellinghaus C. (2011) Atrioventricular block following lacosamide intoxication. Epilepsy Behav 20:725–727.
3. Nizam A, Mylavarapu K, Thomas D, Briskin K, Wu B, Saluja D, Wong S. (2011) Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy. Epilepsia 52:e153–e155.
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