Q: All of the following tetracyclines can be used in renal insufficiency except?

A) Doxycycline
B) Minocycline
C) Demeclocycline
D) Tigecycline


Answer: C

Out of all tetracyclines - Doxycycline, Minocycline and Tigecycline do not require any adjustment in renal dysfunction. Demeclocycline should be avoided in renal dysfunction.Demeclocycline inhibits the renal action of antidiuretic hormone, which may be used as an advantage in the syndrome of inappropriate antidiuretic hormone secretion (SIADH), but should be avoided for any other reasons, if renal insufficiency is present.