Q: What is the mechanism behind Nonimmune (heparin-associated) thrombocytopenia?


Answer: In contrast to Heparin Induced Thrombocytopenia (HIT), a drop within the first two days of heparin exposure is not life threatening, though platelet count may drop down to 100,000/microL. 

This is due to platelet aggregation and no anti-platelet antibodies are produced.

It does not require discontinuation of heparin.