Wednesday, December 13, 2017

Dig. toxicity

Q: One vial of digoxin antibody (Fab) fragments binds how much of digoxin?


Answer:   About 0.5 mg of digoxin 

If there is no time to calculate the dose of antibody (Fab) fragments or can't be calculated, 'rule of thumb' is to use 10 vials for adults or 5 vials for children, in acute ingestion of digoxin toxicity.


Reference:

DigiFab package insert. Savage Laboratories. Melville, NY 2004.

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