Thursday, March 1, 2018

INR correction in severe jaundice

Q: 54 year old male is admitted to ICU with severe jaundice, an elevated international normalized ratio (INR) and elevated Liver Function Test (LFT). If elevated INR gets normalize with vitamin K, what does it imply?

Answer: Probable obstructive Jaundice

An elevated INR that corrects with vitamin K administration implies impaired intestinal absorption of fat-soluble vitamins and the most probable cause is obstructive jaundice. And if, an elevated INR that does not correct with vitamin K, this implies hepatocellular disease causing impaired synthetic function.


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