Q: Out of the following which drug is known as oral pressor?
E) Methylene Blue
Midodrine is an alpha1-agonist. Active metabolite of midodrine is desglymidodrine. It activates alpha-adrenergic receptors of the arteriolar and venous vasculature, resulting in increase in vascular tone. It is an extremely useful drug to use in renal and hepatic patients who frequently require longer ICU stay due to baseline hypotension.
Hydrocortisone is useful only in adrenal insufficiency related hypotension.
Octreotide has been used in conjunction with midodrine for hypotension in diuretic resistant ascites in cirrhotic patients but has no role standing alone.
Clonidine is an anti-hypertensive.
Methylene blue has been used with success in resistant vasoplegia but it is not available in oral form.
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