Q: Out of the following second generation (atypical) antipsychotics, which one is most prone to cause respiratory depression?
Quetiapine is the most widely used second-generation antipsychotic in ICUs in the United States. Out of all, an excess of quetiapine is most likely to cause respiratory depression as well as hypotension.
Ngo A, Ciranni M, Olson KR. Acute quetiapine overdose in adults: a 5-year retrospective case series. Ann Emerg Med 2008; 52:541.