Q: Why Herpes Simplex Virus (HSV)-1 encephalitis is not much common in immunocompromised patients despite high occurrence of mucocutaneous HSV-1 infections in these patients?
Answer: Herpes Simplex Virus (HSV)-1 encephalitis is not much common in immunocompromised patients because most of the brain damage from CNS HSV-1 infection is immune mediated. In immunocompromised patient it has only a mild histopathologic changes.
Pepose JS, Hilborne LH, Cancilla PA, Foos RY. Concurrent herpes simplex and cytomegalovirus retinitis and encephalitis in the acquired immune deficiency syndrome (AIDS). Ophthalmology 1984; 91:1669.