Tuesday, June 26, 2018

Troponin in non cardiac diseases

Q: Elevated troponin can be seen beside acute myocardial infarction in all of the following conditions?

A) Sepsis 
B) Subarachnoid hemorrhage 
C) Pulmonary embolism
D) Aortic dissection
E) All of the above

Answer: E

The objective of above question is to highlight the statement that: "Troponin is highly specific for myocardial cell release, it is not specific for acute coronary syndrome as the cause".

There is a long list of conditions where troponin can be elevated without acute coronary disease.

#cardiology


References:


1. Lim W, Qushmaq I, Devereaux PJ, et al. Elevated cardiac troponin measurements in critically ill patients. Arch Intern Med 2006; 166:2446.

2. Ammann P, Fehr T, Minder EI, et al. Elevation of troponin I in sepsis and septic shock. Intensive Care Med 2001; 27:965. 


3. Arlati S, Brenna S, Prencipe L, et al. Myocardial necrosis in ICU patients with acute non-cardiac disease: a prospective study. Intensive Care Med 2000; 26:31. 

4. Bakshi TK, Choo MK, Edwards CC, et al. Causes of elevated troponin I with a normal coronary angiogram. Intern Med J 2002; 32:520.

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