Fluorescence bronchoscopy

Q: What is Fluorescence bronchoscopy?

Answer:  Fluorescence bronchoscopy can detect pre-invasive lesions such as squamous cell carcinoma which develops a fluorescent property. When combined with the regular bronchoscopy it increases the detection of airway preinvasive lesions, particularly high grade, and biopsies can be taken at the same time. Though technology is still in its nascent stages and has not been studied well it is a hope that by detecting lesions earlier it will reduce the morbidity and mortality of lung cancers.

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References/further reads:

1. Kurie JM, Lee JS, Morice RC, et al. Autofluorescence bronchoscopy in the detection of squamous metaplasia and dysplasia in current and former smokers. J Natl Cancer Inst 1998; 90:991. 1

2. Edell E, Lam S, Pass H, et al. Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. J Thorac Oncol 2009; 4:49.

3. Banerjee AK, Rabbitts PH, George J. Lung cancer. 3: Fluorescence bronchoscopy: clinical dilemmas and research opportunities. Thorax 2003; 58:266.

4. Ikeda N, Honda H, Hayashi A, et al. Early detection of bronchial lesions using newly developed videoendoscopy-based autofluorescence bronchoscopy. Lung Cancer 2006; 52:21.

5.Chiyo M, Shibuya K, Hoshino H, et al. Effective detection of bronchial preinvasive lesions by a new autofluorescence imaging bronchovideoscope system. Lung Cancer 2005; 48:307.

6. Loewen G, Natarajan N, Tan D, et al. Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment. Thorax 2007; 62:335.