Q: Severe hypertriglyceridemia may cause pseudohyponatremia. What is the usual correlation?
Answer: On average, an 886 mg/dL increase in plasma triglycerides reduces the serum sodium concentration by approximately 1 mEq/L.
Dimeski G, Mollee P, Carter A. Effects of hyperlipidemia on plasma sodium, potassium, and chloride measurements by an indirect ion-selective electrode measuring system. Clin Chem 2006; 52:155.