Q: How long one should wait to see the response of benzodiazepine in patients with convulsive status epilepticus before administrating the repeat dose?
Answer: one minute
First line of treatment in patients with convulsive status epilepticus is lorazepam with either the calculated dose of 0.1 mg/kg IV (2 mg/min) or a 4 mg fixed dose. It takes about one minute to see the full response of lorazepam as it is a lipophilic drug. If intravenous access is not available In the pre-hospital 10 mg of intramuscular (IM) midazolam can be given as an alternative.
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Reference:
Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care 2012; 17:3.
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